Saturday, April 26, 2025
The Latest Medical News
A Summary of The Latest Medical News: Adults With ADHD May Face Higher Risk of Dementia, Study Finds
A new study has revealed that adults with ADHD show significant changes in their brains, including higher iron accumulation — changes similar to those seen in early-stage dementia[5].
ADHD and Brain Iron Accumulation
Using MRI scans, researchers identified that adults with ADHD had altered distribution of iron in several brain regions, with particularly heightened levels found in the right precentral cortex and other areas compared to adults without ADHD[4][3][5].
Iron Levels Linked to Brain Cell Damage
The study also found that increased iron in the right precentral cortex was associated with higher concentrations of neurofilament light chain (NfL) in the blood. NfL is a marker connected to neuroaxonal damage — an indicator of ongoing injury to the brain's nerve fibers[5][3].
Medication May Play a Role
Some participants with ADHD were undergoing regular treatment with psychostimulant medications. Other studies referenced suggest that these medications might help normalize iron levels in the brain, but the long-term effects are still uncertain[3].
Potential Link Between ADHD and Dementia
The findings support a growing body of evidence indicating that adults with ADHD may be at greater risk for developing dementia later in life, possibly due to increased iron accumulation disrupting neural function[4][5].
What’s Next for Research
Researchers caution that their sample size was limited, and more long-term studies are necessary to firmly establish whether altered brain iron distribution in individuals with ADHD leads to higher dementia risk as they age[4][5].
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