Wednesday, June 18, 2025
The Latest Medical News
A Summary of The Latest Medical News: **Alzheimer’s Study Links Sitting Time to Higher Disease Risk**
A new study highlights the significant connection between the amount of time older adults spend sedentary and their risk for developing Alzheimer’s disease, regardless of their physical activity levels[1][3][5].
**Sedentary Behavior as an Independent Risk Factor**
Researchers found that older adults who spend more time sitting or lying down faced a higher risk of cognitive decline and brain shrinkage in areas of the brain important for memory and thinking. This connection persisted even among those who met or exceeded recommended exercise levels[1][5].
**Study Methods and Key Findings**
The study included 404 adults aged 50 and older. Participants wore wrist monitors for a week to track movement and sedentary periods. Their cognitive skills and brain health were then followed for seven years using brain scans and cognitive assessments[1][3][5].
**"Reducing Sitting Time Matters"**
Lead researcher Dr. Marissa Gogniat emphasized that regular exercise by itself may not be sufficient to reduce Alzheimer’s risk if daily sitting time remains high[1][5]. Findings showed that those with the most sedentary time saw greater cognitive declines, regardless of their exercise routines[3][5]. On average, participants spent about 13 hours each day sitting, even though 87% met the CDC’s physical activity guidelines[5].
**Genetics Can Amplify the Risk**
The link between sedentary behavior and Alzheimer’s appeared even stronger among participants with the APOE-e4 gene, which is known to increase genetic risk for Alzheimer’s disease[1][5].
**Actionable Takeaway**
Minimizing sitting time throughout the day—by walking, standing, or doing light activities—may offer additional protection for brain health, beyond getting regular exercise[1][5]. For older adults, especially those at higher genetic risk, breaking up long periods of inactivity could be a promising strategy to help preserve memory and cognitive function as they age.
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