Monday, March 31, 2025
The Latest Medical News
A Summary of The Latest Medical News: Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) may help reduce the risk of dementia, according to a recent study published in the Journal of the American Geriatrics Society. The research, conducted by scientists from Erasmus University Medical Center in Rotterdam, Netherlands, analyzed data from over 11,000 participants in the prospective population-based Rotterdam Study.
The study found that individuals who used NSAIDs for more than 24 months had a 12% lower risk of developing dementia compared to non-users. This protective effect was even more pronounced for Alzheimer's disease specifically. Interestingly, short-term and intermediate-term use of NSAIDs (less than 24 months) was associated with a slight increase in dementia risk.
Researchers discovered that the cumulative dose of NSAIDs did not appear to influence the reduced dementia risk. This suggests that the duration of exposure, rather than the intensity, may be the key factor in potentially preventing cognitive decline.
The study also examined different types of NSAIDs, including those known to lower amyloid-β levels in the brain. Surprisingly, NSAIDs without known effects on amyloid-β showed a somewhat stronger association with reduced dementia risk compared to amyloid-lowering NSAIDs.
While these findings are promising, the study authors caution against recommending long-term NSAID use for dementia prevention due to potential adverse effects. Further research is needed to fully understand the relationship between NSAID use and cognitive health, as well as to determine the optimal duration and timing of NSAID use for potential protective effects.
This study adds to the growing body of evidence suggesting a link between inflammation and dementia risk. As our population ages, understanding potential preventive measures for cognitive decline becomes increasingly important for public health.
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